Biomechanical

Publications

Behavior on Intervertebral Disc L4-5 in Pedicle Screw System Instrumented Lumbar Spine

This biomechanics paper analyzes the compression behavior of the L4-5 intervertebral disc in a lumbar spine with a pedicle screw system using a finite element model under a follower load. The study focuses on how the instrumentation alters the segment's flexibility, nucleus pulposus pressure, and the stress distribution within the implant and disc.

Multidirectional Morphology and Mechanics of Osteonic Lamellae

Maria-Grazia Ascenzi and John M. Kabo

This patent describes a novel biomechanical model for human bone based on its hierarchical structure and mechanical properties. The model provides a way to predict bone deformation and fracture, offering a more realistic tool for applications like bone reconstruction and the design of prosthetics.

Modeling and Simulation of Chemomechanics at the Cell-Matrix Interface

This biomechanics paper uses a multiscale computational approach, combining steered molecular dynamics and finite element modeling, to explore the chemomechanics of the cell-matrix interface and how extracellular matrix properties influence cellular processes like adhesion and migration. The study focuses on understanding how matrix stiffness and pH affect ligand-receptor binding at the molecular level and cell-induced deformation at the continuum level.

Comparison of the Bicuspid and Tricuspid Aortic Valves in Relation to Calcific Aortic Stenosis

Eli J. Weinberg, Mohammad R. Kaazempur Mofrad

This biomechanics paper uses multiscale finite-element simulations to compare the fluid-structure interaction and mechanical strains of bicuspid and tricuspid aortic valves, concluding that the differences in cell-scale deformations are not significant enough to explain the higher rate of calcific aortic stenosis in bicuspid valves.

Total Disc Replacement Positioning Affects Facet Contact Forces and Vertebral Body Strains

This biomechanical study uses a finite element model to analyze how the anterior or posterior positioning of a total disc replacement (TDR) implant affects the spine's biomechanics, specifically focusing on facet contact forces and vertebral body strains to better understand the causes of implant complications.