Publications

Publications

Modeling and Simulation of Chemomechanics at the Cell-Matrix Interface

This biomechanics paper uses a multiscale computational approach, combining steered molecular dynamics and finite element modeling, to explore the chemomechanics of the cell-matrix interface and how extracellular matrix properties influence cellular processes like adhesion and migration. The study focuses on understanding how matrix stiffness and pH affect ligand-receptor binding at the molecular level and cell-induced deformation at the continuum level.

Comparison of the Bicuspid and Tricuspid Aortic Valves in Relation to Calcific Aortic Stenosis

Eli J. Weinberg, Mohammad R. Kaazempur Mofrad

This biomechanics paper uses multiscale finite-element simulations to compare the fluid-structure interaction and mechanical strains of bicuspid and tricuspid aortic valves, concluding that the differences in cell-scale deformations are not significant enough to explain the higher rate of calcific aortic stenosis in bicuspid valves.

Total Disc Replacement Positioning Affects Facet Contact Forces and Vertebral Body Strains

This biomechanical study uses a finite element model to analyze how the anterior or posterior positioning of a total disc replacement (TDR) implant affects the spine's biomechanics, specifically focusing on facet contact forces and vertebral body strains to better understand the causes of implant complications.

Strain measurement in the left ventricle during systole with deformable image registration

This paper presents a biomechanical method, Hyperelastic Warping, which combines non-tagged cine-MRI with a finite element model of active fiber contraction and myocardial material properties to measure left ventricular strain during systole. The study validates this approach by demonstrating a strong correlation between its strain predictions and those obtained from conventional tagged MRI, highlighting the potential for more detailed biomechanical analysis of cardiac function.

NAFEMS Finite Element Benchmarks for MDG Code Verification

R.M. Ferencz, R. Greer

This report details the code verification of MDG computational mechanics software using established NAFEMS finite element benchmarks. It systematically compares the MDG code's results against analytical or highly accurate reference solutions provided by NAFEMS to ensure the accuracy of its numerical formulations. The study is crucial for enhancing the reliability and trustworthiness of the MDG software for structural analysis applications.