Abstract:
Cardiovascular pathologies, particularly valvular heart diseases, are a leading cause of mortality globally, with aortic valve and coronary arteries being significant areas of focus due to their prevalence and critical consequences. Conditions like aortic sclerosis alter the micro-structure of the aortic root and valve leaflets, affecting tissue thickness and stiffness, which can impact coronary blood flow. Numerical studies, specifically utilizing Fluid-Structure Interaction (FSI) through advanced computational methods such as Finite Element Analysis, have been instrumental in understanding the biomechanics of the aortic valve, its function, and how pathologies influence cardiac tissue mechanics and local hemodynamics. The interaction between blood and cardiac tissue is crucial for accurately studying the system's response to physiological conditions.
