Biomechanical

Publications

Subject-Specific Finite Element Modeling of the Tibiofemoral Joint In Vivo

This study develops and verifies a subject-specific finite element model of the tibiofemoral joint by combining MRI geometry with in vivo kinematic and contact data. The validated model simulates cartilage and ligament biomechanics during walking, offering critical insights into joint loading, tissue stresses, and clinical applications in orthopedics.

Finite Element Modelling of In Vitro Articular Cartilage Wear in the Patellofemoral Joint

This paper presents a biomechanics-driven computational model simulating cartilage wear in the patellofemoral joint under controlled in vitro conditions. It compares different simulation strategies and imaging sources to validate wear predictions against experimental data, showing that progressive simulations yield more realistic outcomes. The work demonstrates how computational biomechanics can enhance our understanding of joint degeneration mechanisms.

An Open-Source Toolbox for Surrogate Modeling of Joint Contact Mechanics

Ilan Eskinazi and Benjamin J. Fregly

This paper presents the Surrogate Contact Modeling Toolbox (SCMT), an open-source framework for creating fast surrogate models of joint contact mechanics using neural networks. SCMT is designed specifically for biomechanics applications, enabling realistic, efficient musculoskeletal simulations involving joint contact, ligaments, and muscle forces.

Simulations of Single Chondrocyte Versus Anatomically Based Distribution

Jason P. Halloran, Scott C. Sibole, Ahmet Erdemir

"The Potential for Intercellular Mechanical Interaction Simulations of Single Chondrocyte Versus Anatomically Based Distribution" This biomechanical study employs finite element modeling to compare single-cell and anatomically accurate multi-cell representations of chondrocytes within cartilage. It demonstrates that intercellular mechanical interactions significantly affect transient mechanical behaviors, highlighting the importance of realistic cell distributions in predicting cartilage health

Image-Based Cardiac Strain

"Image-Based Cardiac Strain: Progression of Diastolic and Systolic Dysfunction in the Spontaneously Hypertensive Rat" This biomechanical investigation uses advanced imaging and finite element methods to separately quantify diastolic and systolic myocardial strains in spontaneously hypertensive rats. It identifies that diastolic dysfunction precedes systolic impairment, and demonstrates regional variability in cardiac strain, providing insights into mechanical pathways toward heart failure.