Biomechanical

Publications

Strain measurement in the left ventricle during systole with deformable image registration

This paper presents a biomechanical method, Hyperelastic Warping, which combines non-tagged cine-MRI with a finite element model of active fiber contraction and myocardial material properties to measure left ventricular strain during systole. The study validates this approach by demonstrating a strong correlation between its strain predictions and those obtained from conventional tagged MRI, highlighting the potential for more detailed biomechanical analysis of cardiac function.

Incorporation of a Left Ventricle FEM Defining Infarction Into the XCAT Imaging Phantom

This paper enhances the XCAT imaging phantom by incorporating a biomechanically realistic left ventricle finite element model that simulates myocardial infarction. These advanced computational biomechanics tools define infarction size, transmurality, and location, accurately driving pathological cardiac motion and regional wall dysfunction. The research is vital for improving medical imaging applications and understanding diseased heart biomechanics.

Computational Modeling of Keratoconus Progression and Differential Response to Collagen Crosslinking

A. Sinha Roy, W. J. Dupps Jr

A biomechanics-focused finite element model shows that focal reductions in corneal elastic modulus reproduce KC topography and aberrations without thickness loss, and that deeper, cone-centered collagen cross-linking maximizes flattening and optical improvement. Sensitivity to intraocular pressure and stiffening gradients highlights the importance of spatially tailored biomechanical interventions.

Strains at the myotendinous junction predicted by a micromechanical model

B. Sharafi, E. G. Ames, J. W. Holmes, S.S. Blemker

This paper introduces a micromechanical finite element model to predict local strains at the myotendinous junction (MTJ), a common site for muscle injuries. The biomechanical model, validated against histological data, elucidates how MTJ structure and mechanics influence micro-scale muscle fiber strains. This research provides critical insights into muscle injury mechanisms and advances computational biomechanics for tissue-level analysis.

Method for Quantifying the In-Vivo Mechanical Effect of Material Injected in a Myocardial Infarction

By integrating real-time 3DE and biomechanics-driven finite element modeling, this work demonstrates that targeted tissue filler injection into a myocardial infarct can induce akinesia through massive stiffening (~345×), restore ejection fraction, and substantially lower myofiber stress concentrations. Calibration against in vivo volume and strain data highlights the pivotal role of myocardial material properties in governing post-infarction remodeling mechanics.