Abstract:
This study presents an advanced multiscale, three-dimensional computational framework to simulate the transient dynamics of the human aortic valve throughout the cardiac cycle. Combining medical imaging data, anatomical fidelity, and high-resolution finite element analysis, the authors develop a model that captures fluid-structure interactions (FSI) and the biomechanical behavior of the aortic valve leaflets under physiological loading. The model incorporates detailed tissue mechanics, including nonlinear elastic properties and anisotropic behavior of valvular tissue, to provide accurate stress and strain distributions across the cardiac cycle. Hemodynamic forces are simulated in concert with tissue deformation, allowing for time-resolved prediction of valve opening, closing, and the resulting blood flow patterns. The multiscale approach bridges microstructural characteristics of the leaflet tissue with macroscopic valve mechanics and integrates clinically relevant inputs such as valve geometry and flow conditions. This biomechanics-driven work provides insights into normal and pathological valve function, supports the design of valve repair and replacement strategies, and advances personalized cardiovascular modeling.
